The Effect of the New Imidazole Derivatives Complexation with Betacyclodextrin, on the Antifungal Activity in Oropharyngeal Infections

Ketoconazole (KZ) is a broad-spectrum drug used to treat fungal infections. Local use of ketoconazole has been associated with some side effects in healthy adults, especially local reactions, such as stinging, severe irritation, and itching. Moreover, the bioavailability KZ after oral administration low tablets due its water solubility. In addition, produces systemic exposure, significant effects, cholestatic hepatocellular lesions. an attempt reduce hepatotoxicity, may be administered at primary site infection cutaneous candidiasis, specifically on skin tissue. However, topical dosage forms limited by high lipophilicity extremely poor aqueous solubility (1 ng/mL), thus leading rare availability market. Therefore, new approach effective delivery targeted, including obtaining derivatives (keeping imidazolic nucleus), similar spectrum action, finally, their inclusion betacyclodextrin complexes order optimize physico-chemical stability.